CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family | p-hydroxybenzoate hydroxylase |
Enzyme Information
| 1.14.13.2 |
4-hydroxybenzoate 3-monooxygenase.
based on mapping to UniProt P00438
4-hydroxybenzoate + NADPH + O(2) = protocatechuate + NADP(+) + H(2)O.
-!- Most enzymes from Pseudomonas are highly specific for NAD(P)H (cf. EC 1.14.13.33).
|
UniProtKB Entries (1)
| P00438 |
PHHY_PSEFL
Pseudomonas fluorescens
P-hydroxybenzoate hydroxylase
|
PDB Structure
| PDB | 1PBC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring
Biochemistry
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