CATH Classification

Domain Context

CATH Clusters

Superfamily D-Amino Acid Oxidase, subunit A, domain 2
Functional Family p-hydroxybenzoate hydroxylase

Enzyme Information

1.14.13.2
4-hydroxybenzoate 3-monooxygenase.
based on mapping to UniProt P00438
4-hydroxybenzoate + NADPH + O(2) = protocatechuate + NADP(+) + H(2)O.
-!- Most enzymes from Pseudomonas are highly specific for NAD(P)H (cf. EC 1.14.13.33).

UniProtKB Entries (1)

P00438
PHHY_PSEFL
Pseudomonas fluorescens
P-hydroxybenzoate hydroxylase

PDB Structure

PDB 1PBB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring
Schreuder, H.A., Mattevi, A., Obmolova, G., Kalk, K.H., Hol, W.G., van der Bolt, F.J., van Berkel, W.J.
Biochemistry