CATH Domain 1pafA02

CATH Classification

Level	CATH Code	Description
	4	Few Secondary Structures
	4.10	Irregular
	4.10.470	Ricin (A Subunit), domain 2
	4.10.470.10	Ricin (A Subunit), domain 2

Domain Context

CATH Clusters

Superfamily	Ricin (A Subunit), domain 2
Functional Family	Antiviral protein I

Enzyme Information

3.2.2.22

rRNA N-glycosylase.

based on mapping to UniProt P10297

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P10297

RIP1_PHYAM

Phytolacca americana

Antiviral protein I

PDB Structure

PDB	1PAF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The 2.5 A structure of pokeweed antiviral protein. Monzingo, A.F., Collins, E.J., Ernst, S.R., Irvin, J.D., Robertus, J.D. J.Mol.Biol.