CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.140 | Cytidine Deaminase; domain 2 |
|
3.40.140.20 | AICAR transformylase, duplication domain |
Domain Context
CATH Clusters
| Superfamily | 3.40.140.20 |
| Functional Family | Bifunctional purine biosynthesis protein PURH |
Enzyme Information
| 2.1.2.3 |
Phosphoribosylaminoimidazolecarboxamide formyltransferase.
based on mapping to UniProt P31939
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.
|
| 3.5.4.10 |
IMP cyclohydrolase.
based on mapping to UniProt P31939
IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
|
UniProtKB Entries (1)
| P31939 |
PUR9_HUMAN
Homo sapiens
Bifunctional purine biosynthesis protein PURH
|
PDB Structure
| PDB | 1P4R |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates
J.Biol.Chem.
|
