CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.640 | Aspartate Aminotransferase; domain 2 | |
3.40.640.10 | Type I PLP-dependent aspartate aminotransferase-like (Major domain) |
Domain Context
CATH Clusters
Superfamily | Type I PLP-dependent aspartate aminotransferase-like (Major domain) |
Functional Family | Aspartate aminotransferase |
Enzyme Information
2.6.1.1 |
Aspartate transaminase.
based on mapping to UniProt P00508
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
-!- Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. -!- This activity can be formed from EC 2.6.1.57 by controlled proteolysis.
|
2.6.1.7 |
Kynurenine--oxoglutarate transaminase.
based on mapping to UniProt P00508
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
-!- Also acts on 3-hydroxykynurenine. -!- The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
|
UniProtKB Entries (1)
P00508 |
AATM_CHICK
Gallus gallus
Aspartate aminotransferase, mitochondrial
|
PDB Structure
PDB | 1OXP |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structures and solution studies of oxime adducts of mitochondrial aspartate aminotransferase.
Eur.J.Biochem.
|