CATH Domain 1oxgA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Chymotrypsinogen A

Enzyme Information

3.4.21.1

Chymotrypsin.

based on mapping to UniProt P00766

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

-!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.5 and EC 3.4.4.6.

UniProtKB Entries (1)

CTRA_BOVIN

Bos taurus

Chymotrypsinogen A

PDB Structure

PDB	1OXG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Detection of native peptides as potent inhibitors of enzymes. Crystal structure of the complex formed between treated bovine alpha-chymotrypsin and an autocatalytically produced fragment, IIe-Val-Asn-Gly-Glu-Glu-Ala-Val-Pro-Gly-Ser-Trp-Pro-Trp, at 2.2 angstroms resolution. Singh, N., Jabeen, T., Sharma, S., Roy, I., Gupta, M.N., Bilgrami, S., Somvanshi, R.K., Dey, S., Perbandt, M., Betzel, C., Srinivasan, A., Singh, T.P. Febs J.