CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.60 | Phosphoenolpyruvate-binding domains |
Domain Context
CATH Clusters
| Superfamily | Phosphoenolpyruvate-binding domains |
| Functional Family | 2-methylisocitrate lyase |
Enzyme Information
| 4.1.3.30 |
Methylisocitrate lyase.
based on mapping to UniProt P77541
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.
-!- Acts on threo-D(s)-2-methylisocitrate, but not on threo-D(s)- isocitrate, threo-DL-isocitrate or erythro-L(s)-isocitrate.
|
UniProtKB Entries (1)
| P77541 |
PRPB_ECOLI
Escherichia coli K-12
2-methylisocitrate lyase
|
PDB Structure
| PDB | 1OQF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structures of 2-methylisocitrate lyase in complex with product and with isocitrate inhibitor provide insight into lyase substrate specificity, catalysis and evolution.
Biochemistry
|
