CATH Domain 1op8A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Complement factor D

Enzyme Information

3.4.21.78

Granzyme A.

based on mapping to UniProt P12544

Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|- Xaa- in small molecule substrates.

-!- From cytotoxic T lymphocyte granules. -!- The human enzyme does not cleave Phe-|-Xaa. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P12544

GRAA_HUMAN

Homo sapiens

Granzyme A

PDB Structure

PDB	1OP8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of the apoptosis-inducing human granzyme A dimer Hink-Schauer, C., Estebanez-Perpina, E., Kurschus, F., Bode, W., Jenne, D. NAT.STRUCT.BIOL.