CATH Domain 1onzA00

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.190	Protein-Tyrosine Phosphatase; Chain A
	3.90.190.10	Protein tyrosine phosphatase superfamily

Superfamily	Protein tyrosine phosphatase superfamily
Functional Family	Tyrosine-protein phosphatase non-receptor type 1

3.1.3.48

Protein-tyrosine-phosphatase.

based on mapping to UniProt P18031

Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

PTN1_HUMAN

Homo sapiens

Tyrosine-protein phosphatase non-receptor type 1

PDB	1ONZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B Liu, G., Szczepankiewicz, B.G., Pei, Z., Janowich, D.A., Xin, Z., Hadjuk, P.J., Abad-Zapatero, C., Liang, H., Hutchins, C.W., Fesik, S.W., Ballaron, S.J., Stashko, M.A., Lubben, T., Mika, A.K., Zinker, B.A., Trevillyan, J.M., Jirousek, M.R. J.Med.Chem.