CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.10 | Orthogonal Bundle |
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1.10.1740 | Rna Polymerase Sigma Factor; Chain: A |
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1.10.1740.10 | RNA polymerase sigma factor, region 2, helix turn helix motif |
Domain Context
CATH Clusters
Superfamily | 1.10.1740.10 |
Functional Family | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
Enzyme Information
1.1.1.267 |
1-deoxy-D-xylulose-5-phosphate reductoisomerase.
based on mapping to UniProt P45568
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.
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UniProtKB Entries (1)
P45568 |
DXR_ECOLI
Escherichia coli K-12
1-deoxy-D-xylulose 5-phosphate reductoisomerase
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PDB Structure
PDB | 1ONP |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol
4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria
drug development.
J.BIOL.CHEM.
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