CATH Domain 1ok6G00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family

Enzyme Information

4.1.2.13

Fructose-bisphosphate aldolase.

based on mapping to UniProt P58315

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

-!- Also acts on (3S,4R)-ketose 1-phosphates. -!- The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc. -!- Formerly EC 4.1.2.7.

UniProtKB Entries (1)

P58315

ALF1_THETK

Thermoproteus tenax Kra 1

Fructose-bisphosphate aldolase class 1

PDB Structure

PDB	1OK6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of an archaeal class I aldolase and the evolution of (betaalpha)8 barrel proteins. Lorentzen, E., Pohl, E., Zwart, P., Stark, A., Russell, R.B., Knura, T., Hensel, R., Siebers, B. J. Biol. Chem.