CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.170 | Beta Complex |
|
2.170.11 | DNA Topoisomerase I; domain 2 |
|
2.170.11.10 | DNA Topoisomerase I, domain 2 |
Domain Context
CATH Clusters
| Superfamily | DNA Topoisomerase I, domain 2 |
| Functional Family | DNA topoisomerase I |
Enzyme Information
| 5.6.2.2 |
DNA topoisomerase.
based on mapping to UniProt P04786
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3. -!- Formerly EC 5.99.1.2.
|
UniProtKB Entries (1)
| P04786 |
TOP1_YEAST
Saccharomyces cerevisiae S288C
DNA topoisomerase 1
|
PDB Structure
| PDB | 1OIS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Saccharomyces |
| Primary Citation |
A 26 kDa yeast DNA topoisomerase I fragment: crystallographic structure and mechanistic implications.
Structure
|