CATH Domain 1ohyA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1150	Aspartate Aminotransferase, domain 1
	3.90.1150.10	Aspartate Aminotransferase, domain 1

Domain Context

CATH Clusters

Superfamily	Aspartate Aminotransferase, domain 1
Functional Family	4-aminobutyrate aminotransferase, mitochondrial

Enzyme Information

2.6.1.22

(S)-3-amino-2-methylpropionate transaminase.

based on mapping to UniProt P80147

(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3- oxopropanoate + L-glutamate.

-!- Also acts on beta-alanine and other omega-amino acids having carbon chains between 2 and 5. -!- The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.40, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.

2.6.1.19

4-aminobutyrate--2-oxoglutarate transaminase.

based on mapping to UniProt P80147

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.

-!- Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate.

UniProtKB Entries (1)

P80147

GABT_PIG

Sus scrofa

4-aminobutyrate aminotransferase, mitochondrial

PDB Structure

PDB	1OHY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structures of {Gamma}-Aminobutyric Acid (Gaba) Aminotransferase, a Pyridoxal 5'-Phosphate, and [2Fe-2S] Cluster-Containing Enzyme, Complexed with {Gamma}-Ethynyl-Gaba and with the Antiepilepsy Drug Vigabatrin Storici, P., De Biase, D., Bossa, F., Bruno, S., Mozzarelli, A., Peneff, C., Silverman, R., Schirmer, T. J.Biol.Chem.