CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family |
Enzyme Information
| 2.1.1.209 |
23S rRNA (guanine(2535)-N(1))-methyltransferase.
based on mapping to UniProt Q9F5K5
S-adenosyl-L-methionine + guanine(2535) in 23S rRNA = S-adenosyl-L- homocysteine + N(1)-methylguanine(2535) in 23S rRNA.
-!- Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. -!- To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (guanine(2535)-N(1))- methyltransferase and EC 2.1.1.208 whose actions confer avilamycin resistance to the RNA.
|
UniProtKB Entries (1)
| Q9F5K5 |
AVRA_STRVR
Streptomyces viridochromogenes
23S rRNA (guanine(2535)-N(1))-methyltransferase
|
PDB Structure
| PDB | 1O9G |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of the Avilamycin Resistance-Conferring Methyltransferase Avira from Streptomyces Viridochromogenes
J.Mol.Biol.
|
