CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Prolyl endopeptidase

Enzyme Information

3.4.21.26
Prolyl oligopeptidase.
based on mapping to UniProt P23687
Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.
-!- Found in vertebrates, plants and Flavobacterium. -!- Generally cytosolic, commonly activated by thiol compounds. -!- Belongs to peptidase family S9A. -!- Formerly EC 3.4.22.18.

UniProtKB Entries (1)

P23687
PPCE_PIG
Sus scrofa
Prolyl endopeptidase

PDB Structure

PDB 1O6F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase.
Szeltner, Z., Rea, D., Juhasz, T., Renner, V., Mucsi, Z., Orosz, G., Fulop, V., Polgar, L.
J. Biol. Chem.
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