CATH Domain 1nwwA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.450	Nuclear Transport Factor 2; Chain: A,
	3.10.450.50

Domain Context

CATH Clusters

Superfamily	3.10.450.50
Functional Family

Enzyme Information

3.3.2.8

Limonene-1,2-epoxide hydrolase.

based on mapping to UniProt Q9ZAG3

1,2-epoxymenth-8-ene + H(2)O = menth-8-ene-1,2-diol.

-!- Involved in the monoterpene degradation pathway of the actinomycete Rhodococcus erythropolis. -!- The enzyme hydrolyzes several alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide. -!- It differs from the previously described epoxide hydrolases (EC 3.3.2.4, EC 3.3.2.6, EC 3.3.2.7, EC 3.3.2.9 and EC 3.3.2.10) as it is not inhibited by 2-bromo-4'-nitroacetophenone, diethyl pyrocarbonate, 4-fluorochalcone oxide or 1,10-phenanthroline.

UniProtKB Entries (1)

Q9ZAG3

LIMA_RHOER

Rhodococcus erythropolis

Limonene-1,2-epoxide hydrolase

PDB Structure

PDB	1NWW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site Arand, M., Hallberg, B.M., Zou, J., Bergfors, T., Oesch, F., van der Werf, M.J., de Bont, J.A.M., Jones, T.A., Mowbray, S.L. EMBO J.