CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Histone-lysine N-methyltransferase, H3 lysine-79 specific

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q8TEK3
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q8TEK3
DOT1L_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase, H3 lysine-79 specific

PDB Structure

PDB 1NW3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase
Min, J., Feng, Q., Li, Z., Zhang, Y., Xu, R.M.
Cell(Cambridge,Mass.)