CATH Domain 1nvuS02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.840	Son of Sevenless (SoS) protein; Chain S, domain 2
	1.10.840.10	Ras guanine-nucleotide exchange factors catalytic domain

Domain Context

CATH Clusters

Superfamily	Ras guanine-nucleotide exchange factors catalytic domain
Functional Family	son of sevenless homolog 1 isoform X2

Enzyme Information

UniProtKB Entries (1)

SOS1_HUMAN

Homo sapiens

Son of sevenless homolog 1

PDB Structure

PDB	1NVU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS Margarit, S.M., Sondermann, H., Hall, B.E., Nagar, B., Hoelz, A., Pirruccello, M., Bar-Sagi, D., Kuriyan, J. Cell(Cambridge,Mass.)