CATH Domain 1nvjA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1170	Aldehyde Oxidoreductase; domain 3
	3.90.1170.40	Molybdopterin biosynthesis MoaE subunit

Domain Context

CATH Clusters

Superfamily	Molybdopterin biosynthesis MoaE subunit
Functional Family	Molybdopterin synthase catalytic subunit MoaE

Enzyme Information

2.8.1.12

Molybdopterin synthase.

based on mapping to UniProt P30749

Cyclic pyranopterin phosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + H(2)O = molybdopterin + 2 [molybdopterin- synthase sulfur-carrier protein].

-!- Catalyzes the synthesis of molybdopterin from cyclic pyranopterin phosphate. -!- Two sulfur atoms are transferred to cyclic pyranopterin phosphate in order to form the characteristic ene-dithiol group found in the molybdenum cofactor. -!- Molybdopterin synthase consists of two large subunits forming a central dimer and two small subunits (molybdopterin-synthase sulfur- carrier proteins) that are thiocarboxylated at the C-terminus by EC 2.8.1.11, molybdopterin synthase sulfurtransferase. -!- The reaction occurs in prokaryotes and eukaryotes.

UniProtKB Entries (1)

P30749

MOAE_ECOLI

Escherichia coli K-12

Molybdopterin synthase catalytic subunit

PDB Structure

PDB	1NVJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural Studies of Molybdopterin Synthase Provide Insights into its Catalytic Mechanism Rudolph, M.J., Wuebbens, M.M., Turque, O., Rajagopalan, K.V., Schindelin, H. J.Biol.Chem.