CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.20 | Up-down Bundle | |
1.20.120 | Four Helix Bundle (Hemerythrin (Met), subunit A) | |
1.20.120.150 | FKBP12-rapamycin binding domain |
Domain Context
CATH Clusters
Superfamily | FKBP12-rapamycin binding domain |
Functional Family | Serine/threonine-protein kinase TOR |
Enzyme Information
2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P42345
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
UniProtKB Entries (1)
P42345 |
MTOR_HUMAN
Homo sapiens
Serine/threonine-protein kinase mTOR
|
PDB Structure
PDB | 1NSG |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D
|