CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family DNA polymerase I

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P52026
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P52026
DPO1_GEOSE
Geobacillus stearothermophilus
DNA polymerase I

PDB Structure

PDB 1NK7
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of mismatch replication errors observed in a DNA polymerase.
Johnson, S.J., Beese, L.S.
Cell(Cambridge,Mass.)