CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A Subunit), domain 2
Functional Family

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P22851
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P22851
RIPB_LUFAE
Luffa aegyptiaca
Ribosome-inactivating protein luffin-B

PDB Structure

PDB 1NIO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of beta-luffin, a ribosome-inactivating protein, at 2.0 A resolution.
Ma, Q.J., Li, J.H., Li, H.G., Wu, S., Dong, Y.C.
Acta Crystallogr.,Sect.D