CATH Classification
Domain Context
CATH Clusters
Superfamily | Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A |
Functional Family | beta-1,4-galactosyltransferase 1 |
Enzyme Information
2.4.1.90 |
N-acetyllactosamine synthase.
based on mapping to UniProt P08037
UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.
-!- The reaction is catalyzed by a component of EC 2.4.1.22, which is identical with EC 2.4.1.38, and by an enzyme from the Golgi apparatus of animal tissues. -!- Formerly EC 2.4.1.98.
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2.4.1.38 |
Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase.
based on mapping to UniProt P08037
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide.
-!- Terminal N-acetyl-beta-D-glucosaminyl residues in polysaccharides, glycoproteins and glycopeptides can act as acceptor. -!- High activity is shown toward such residues in branched-chain polysaccharides when these are linked by beta-1,6 links to galactose residues; lower activity toward residues linked to galactose by beta- 1,3 links. -!- A component of EC 2.4.1.22.
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2.4.1.22 |
Lactose synthase.
based on mapping to UniProt P08037
UDP-alpha-D-galactose + D-glucose = UDP + lactose.
-!- The enzyme is a complex of 2 proteins A and B. -!- In the absence of the B protein (alpha-lactalbumin) the enzyme catalyzes the transfer of galactose from UDP-galactose to N-acetylglucosamine (cf. EC 2.4.1.90).
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2.4.1.- |
Hexosyltransferases.
based on mapping to UniProt P08037
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UniProtKB Entries (2)
P29752 |
LALBA_MOUSE
Mus musculus
Alpha-lactalbumin
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P08037 |
B4GT1_BOVIN
Bos taurus
Beta-1,4-galactosyltransferase 1
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PDB Structure
PDB | 1NF5 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal Structure of Lactose Synthase Reveals a Large Conformational Change in its Catalytic Component, the beta-1,4-galactosyltransferase
J.Mol.Biol.
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