CATH Domain 1nc6A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Cationic trypsin

Enzyme Information

3.4.21.4

Trypsin.

based on mapping to UniProt P00760

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

-!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.4.

UniProtKB Entries (1)

TRY1_BOVIN

Bos taurus

Cationic trypsin

PDB Structure

PDB	1NC6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone. Costanzo, M.J., Yabut, S.C., Almond Jr., H.R., Andrade-Gordon, P., Corcoran, T.W., De Garavilla, L., Kauffman, J.A., Abraham, W.M., Recacha, R., Chattopadhyay, D., Maryanoff, B.E. J.Med.Chem.