CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family

Enzyme Information

1.1.99.18
Cellobiose dehydrogenase (acceptor).
based on mapping to UniProt Q01738
Cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor.
-!- Also acts, more slowly, on cello-oligosaccharides, lactose and D-glucosyl-1,4-beta-D-mannose. -!- The enzyme from the white rot fungus Phanerochaete chrysosporium is unusual in having two redoxin domains, one containing a flavin and the other a protoheme group. -!- It transfers reducing equivalents from cellobiose to two types of redox acceptor: two-electron oxidants, including redox dyes, benzoquinones, and molecular oxygen, and one-electron oxidants, including semiquinone species, iron(II) complexes, and the model acceptor cytochrome c. -!- 2,6-dichloroindophenol can act as acceptor in vitro.

UniProtKB Entries (1)

Q01738
CDH_PHACH
Phanerochaete chrysosporium
Cellobiose dehydrogenase

PDB Structure

PDB 1NAA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism of the reductive half-reaction in cellobiose dehydrogenase
Hallberg, B.M., Henriksson, G., Pettersson, G., Vasella, A., Divne, C.
J.BIOL.CHEM.