CATH Domain 1n8iA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.360	Malate synthase, domain 3

Domain Context

CATH Clusters

Superfamily	Malate synthase, domain 3
Functional Family	Malate synthase G

Enzyme Information

2.3.3.9

Malate synthase.

based on mapping to UniProt P9WK16

Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.

-!- The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. -!- Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO(2). -!- Formerly EC 4.1.3.2.

UniProtKB Entries (1)

P9WK16

MASZ_MYCTO

Mycobacterium tuberculosis CDC1551

Malate synthase G

PDB Structure

PDB	1N8I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis Smith, C.V., Huang, C.C., Miczak, A., Russell, D.G., Sacchettini, J.C., Honer Zu Bentrup, K. J.Biol.Chem.