CATH Domain 1n5dA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Carbonyl reductase [NADPH] 1

Enzyme Information

1.1.1.197	15-hydroxyprostaglandin dehydrogenase (NADP(+)). based on mapping to UniProt Q28960 (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)- 11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH. -!- Acts on prostaglandins E(2), F(2)-alpha and B(1), but not on prostaglandin D(2) (cf. EC 1.1.1.141 and EC 1.1.1.196). -!- May be identical with EC 1.1.1.189.
1.1.1.189	Prostaglandin-E(2) 9-reductase. based on mapping to UniProt Q28960 (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. -!- Reduces prostaglandin E(2) to prostaglandin F(2)-alpha. -!- A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds. -!- May be identical with EC 1.1.1.197.
1.1.1.184	Carbonyl reductase (NADPH). based on mapping to UniProt Q28960 R-CHOH-R' + NADP(+) = R-CO-R' + NADPH. -!- Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol. -!- Si-specific with respect to NADPH (cf. EC 1.1.1.2).

UniProtKB Entries (1)

CBR1_PIG

Sus scrofa

Carbonyl reductase [NADPH] 1

PDB Structure

PDB	1N5D
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Porcine Carbonyl Reductase: Structural Basis for a Functional Monomer in Short-Chain Dehydrogenases/Reductases Ghosh, D., Sawicki, M., Pletnev, V., Erman, M., Duax, W.L., Ohno, S., Nakajin, S. J.Biol.Chem.