CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.600 | Farnesyl Diphosphate Synthase |
|
1.10.600.10 | Farnesyl Diphosphate Synthase |
Domain Context
CATH Clusters
| Superfamily | Farnesyl Diphosphate Synthase |
| Functional Family | Isoprene synthase, chloroplastic |
Enzyme Information
| 4.2.3.116 |
(+)-camphene synthase.
based on mapping to UniProt O81192
Geranyl diphosphate = (+)-camphene + diphosphate.
-!- Cyclase I of Salvia officinalis (sage) gives about equal parts (+)- camphene and (+)-alpha-pinene. -!- (3R)-linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate. -!- See also EC 4.2.3.121.
|
| 4.2.3.121 |
(+)-alpha-pinene synthase.
based on mapping to UniProt O81192
Geranyl diphosphate = (+)-alpha-pinene + diphosphate.
-!- Cyclase I of Salvia officinalis (sage) gives about equal parts (+)- alpha-pinene and (+)-camphene, whereas cyclase III gives about equal parts of (+)-alpha-pinene and (+)-beta-pinene. -!- (3R)-linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate. -!- The 4-pro-R hydrogen of geranyl diphosphate is lost. -!- With synthase II of Pinus taeda (loblolly pine) (+)-beta-pinene was the only product. -!- See also EC 4.2.3.122 and EC 4.2.3.116.
|
| 5.5.1.8 |
(+)-bornyl diphosphate synthase.
based on mapping to UniProt O81192
Geranyl diphosphate = (+)-bornyl diphosphate.
-!- The enzyme from Salvia officinalis (sage) can also use (3R)-linalyl diphosphate or more slowly neryl diphosphate in vitro. -!- The reaction proceeds via isomeration of geranyl diphosphate to (3R)- linalyl diphosphate. -!- The oxygen and phosphorus originally linked to C-1 of geranyl diphosphate end up linked to C-2 of (+)-bornyl diphosphate. -!- cf. EC 5.5.1.22.
|
UniProtKB Entries (1)
| O81192 |
BPPS_SALOF
Salvia officinalis
(+)-bornyl diphosphate synthase, chloroplastic
|
PDB Structure
| PDB | 1N20 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Bornyl Diphosphate Synthase: Structure and Strategy for Carbocation Manipulation by a Terpenoid Cyclase
Proc.Natl.Acad.Sci.USA
|
