CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.450.40
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.17
3',5'-cyclic-nucleotide phosphodiesterase.
based on mapping to UniProt Q922S4
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.

UniProtKB Entries (1)

Q922S4
PDE2A_MOUSE
Mus musculus
CGMP-dependent 3',5'-cyclic phosphodiesterase

PDB Structure

PDB 1MC0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding.
Martinez, S.E., Wu, A.Y., Glavas, N.A., Tang, X.B., Turley, S., Hol, W.G., Beavo, J.A.
Proc.Natl.Acad.Sci.USA