CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.50 | OB fold (Dihydrolipoamide Acetyltransferase, E2P) |
|
2.40.50.930 |
Domain Context
CATH Clusters
| Superfamily | 2.40.50.930 |
| Functional Family | Serine/threonine-protein kinase PLK4 |
Enzyme Information
| 2.7.11.21 |
Polo kinase.
based on mapping to UniProt Q64702
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
| Q64702 |
PLK4_MOUSE
Mus musculus
Serine/threonine-protein kinase PLK4
|
PDB Structure
| PDB | 1MBY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization.
Nat.Struct.Biol.
|
