CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P00520
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00520
ABL1_MOUSE
Mus musculus
Tyrosine-protein kinase ABL1

PDB Structure

PDB 1M52
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and Imatinib (STI-571)
Nagar, B., Bornmann, W., Pellicena, P., Schindler, T., Veach, D., Miller, W.T., Clarkson, B., Kuriyan, J.
Cancer Res.
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