CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.70 | Cathepsin D, subunit A; domain 1 |
|
2.40.70.10 | Acid Proteases |
Domain Context
CATH Clusters
| Superfamily | Acid Proteases |
| Functional Family | Cathepsin D preproprotein |
Enzyme Information
| 3.4.23.5 |
Cathepsin D.
based on mapping to UniProt P07339
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.
-!- Occurs intracellularly, in lysosomes. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.23.
|
UniProtKB Entries (1)
| P07339 |
CATD_HUMAN
Homo sapiens
Cathepsin D
|
PDB Structure
| PDB | 1LYW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Conformational switching in an aspartic proteinase.
Nat.Struct.Biol.
|
