CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.29 | PH-domain like |
|
2.30.29.30 | Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) |
Domain Context
CATH Clusters
| Superfamily | Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) |
| Functional Family | Myotubularin 1, isoform CRA_a |
Enzyme Information
| 3.1.3.64 |
Phosphatidylinositol-3-phosphatase.
based on mapping to UniProt Q13614
1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol + phosphate.
-!- This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyzes Ins(1,3)P(2) to Ins-1-P. -!- Formerly EC 3.1.3.65.
|
| 3.1.3.95 |
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase.
based on mapping to UniProt Q13614
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol 5-phosphate + phosphate.
-!- The enzyme is found in both plants and animals. -!- It also has the activity of EC 3.1.3.64.
|
UniProtKB Entries (1)
| Q13614 |
MTMR2_HUMAN
Homo sapiens
Myotubularin-related protein 2
|
PDB Structure
| PDB | 1LW3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal Structure of a Phosphoinositide Phosphatase, MTMR2: Insights into Myotubular Myopathy and Charcot-Marie-Tooth Syndrome
Mol.Cell
|