CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.45 | Peptide Deformylase |
|
3.90.45.10 | Peptide deformylase |
Domain Context
CATH Clusters
| Superfamily | Peptide deformylase |
| Functional Family | Peptide deformylase |
Enzyme Information
| 3.5.1.88 |
Peptide deformylase.
based on mapping to UniProt P0A6K3
Formyl-L-methionyl peptide + H(2)O = formate + methionyl peptide.
-!- Requires at least a dipeptide for an efficient rate of reaction. -!- N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. -!- Differs in substrate specificity from EC 3.5.1.27 and EC 3.5.1.31.
|
UniProtKB Entries (1)
| P0A6K3 |
DEF_ECOLI
Escherichia coli K-12
Peptide deformylase
|
PDB Structure
| PDB | 1LRU |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.
J.Mol.Biol.
|
