CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.60 | Lipoxygenase-1 |
|
2.60.60.20 | PLAT/LH2 domain |
Domain Context
CATH Clusters
| Superfamily | PLAT/LH2 domain |
| Functional Family | Arachidonate 5-lipoxygenase a |
Enzyme Information
| 1.13.11.33 |
Arachidonate 15-lipoxygenase.
based on mapping to UniProt P12530
Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa- 5,8,11,13-tetraenoate.
-!- The product is rapidly converted to the corresponding 15S-hydroxy compound.
|
| 1.13.11.31 |
Arachidonate 12-lipoxygenase.
based on mapping to UniProt P12530
Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa- 5,8,10,14-tetraenoate.
-!- The product is rapidly reduced to the corresponding 12S-hydroxy compound.
|
UniProtKB Entries (1)
| P12530 |
LOX15_RABIT
Oryctolagus cuniculus
Arachidonate 15-lipoxygenase
|
PDB Structure
| PDB | 1LOX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity.
Nat.Struct.Biol.
|
