CATH Domain 1lmhA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.45	Peptide Deformylase
	3.90.45.10	Peptide deformylase

Domain Context

CATH Clusters

Superfamily	Peptide deformylase
Functional Family	Peptide deformylase

Enzyme Information

3.5.1.88

Peptide deformylase.

based on mapping to UniProt P68826

Formyl-L-methionyl peptide + H(2)O = formate + methionyl peptide.

-!- Requires at least a dipeptide for an efficient rate of reaction. -!- N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. -!- Differs in substrate specificity from EC 3.5.1.27 and EC 3.5.1.31.

UniProtKB Entries (1)

P68826

DEF_STAAU

Staphylococcus aureus

Peptide deformylase

PDB Structure

PDB	1LMH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal Structure of Type II peptide deformylase from Staphylococcus aureus Baldwin, E.T., Harris, M.S., Yem, A.W., Wolfe, C.L., Vosters, A.F., Curry, K.A., Murray, R.W., Bock, J.H., Marshall, V.P., Cialdella, J.I., Merchant, M.H., Choi, G., Deibel Jr., M.R. J.Biol.Chem.