CATH Domain 1lcyA03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.42	Pdz3 Domain
	2.30.42.10	PDZ domain

Domain Context

CATH Clusters

Superfamily	2.30.42.10
Functional Family	serine protease HTRA2, mitochondrial

Enzyme Information

3.4.21.108

HtrA2 peptidase.

based on mapping to UniProt O43464

Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues.

-!- Up-regulated in mammalian cells in response to stress induced by both heat shock and tunicamycin treatment. -!- Can induce apoptosis in a caspase-independent manner through its peptidase activity and in a caspase-dependent manner by disrupting the interaction between caspase and the inhibitor of apoptosis (IAP). -!- Belongs to peptidase family S1B.

UniProtKB Entries (1)

O43464

HTRA2_HUMAN

Homo sapiens

Serine protease HTRA2, mitochondrial

PDB Structure

PDB	1LCY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi. Li, W., Srinivasula, S.M., Chai, J., Li, P., Wu, J.W., Zhang, Z., Alnemri, E.S., Shi, Y. Nat.Struct.Biol.