CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.1200.10
Functional Family

Enzyme Information

2.7.1.95
Kanamycin kinase.
based on mapping to UniProt P0A3Y5
ATP + kanamycin = ADP + kanamycin 3'-phosphate.
-!- Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. -!- An enzyme from Pseudomonas aeruginosa also acts on butirosin.

UniProtKB Entries (1)

P0A3Y5
KKA3_ENTFL
Enterococcus faecalis
Aminoglycoside 3'-phosphotransferase

PDB Structure

PDB 1L8T
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry.
Fong, D.H., Berghuis, A.M.
EMBO J.