CATH Domain 1l5jA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1060	Aconitase; Domain 2
	3.40.1060.10	Aconitase, Domain 2

Domain Context

CATH Clusters

Superfamily	Aconitase, Domain 2
Functional Family	Aconitate hydratase B

Enzyme Information

4.2.1.99

2-methylisocitrate dehydratase.

based on mapping to UniProt P36683

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3- tricarboxylate + H(2)O.

-!- The enzyme from the fungus Yarrowia lipolytica does not act on isocitrate.

4.2.1.3

Aconitate hydratase.

based on mapping to UniProt P36683

Citrate = isocitrate.

-!- Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. -!- The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. -!- Cis-aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3- tricarboxylate. -!- Formerly EC 4.2.1.4.

UniProtKB Entries (1)

P36683

ACNB_ECOLI

Escherichia coli K-12

Aconitate hydratase B

PDB Structure

PDB	1L5J
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	E. coli aconitase B structure reveals a HEAT-like domain with implications for protein-protein recognition. Williams, C.H., Stillman, T.J., Barynin, V.V., Sedelnikova, S.E., Tang, Y., Green, J., Guest, J.R., Artymiuk, P.J. Nat.Struct.Biol.