CATH Classification
Domain Context
CATH Clusters
| Superfamily | Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain |
| Functional Family | Succinate dehydrogenase flavoprotein subunit (SdhA) |
Enzyme Information
| 1.3.5.4 |
Fumarate reductase (quinol).
based on mapping to UniProt P00363
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. -!- The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.
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UniProtKB Entries (1)
| P0AC47 |
FRDB_ECOLI
Escherichia coli K-12
Fumarate reductase iron-sulfur subunit
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PDB Structure
| PDB | 1L0V |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site.
J.Biol.Chem.
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