CATH Domain 1ky4A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Adenosylhomocysteinase

Enzyme Information

3.3.1.1

Adenosylhomocysteinase.

based on mapping to UniProt P10760

S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.

-!- The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.

UniProtKB Entries (1)

P10760

SAHH_RAT

Rattus norvegicus

Adenosylhomocysteinase

PDB Structure

PDB	1KY4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Catalytic Mechanism of S-adenosylhomocysteine Hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190. Takata, Y., Yamada, T., Huang, Y., Komoto, J., Gomi, T., Ogawa, H., Fujioka, M., Takusagawa, F. J.Biol.Chem.