CATH Domain 1ktzB00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.60	CD59
	2.10.60.10	CD59

Domain Context

CATH Clusters

Superfamily	CD59
Functional Family	TGF-beta receptor type-2

Enzyme Information

2.7.11.30

Receptor protein serine/threonine kinase.

based on mapping to UniProt P37173

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P37173

TGFR2_HUMAN

Homo sapiens

TGF-beta receptor type-2

PDB Structure

PDB	1KTZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex. Hart, P.J., Deep, S., Taylor, A.B., Shu, Z., Hinck, C.S., Hinck, A.P. Nat.Struct.Biol.