CATH Classification

Domain Context

CATH Clusters

Superfamily Pseudouridine synthase
Functional Family

Enzyme Information

5.4.99.19
16S rRNA pseudouridine(516) synthase.
based on mapping to UniProt P0AA43
16S rRNA uridine(516) = 16S rRNA pseudouridine(516).
-!- The enzyme is specific for uridine(516) in 16S rRNA. -!- In vitro, the enzyme does not modify free 16S rRNA. -!- The preferred substrate is a 5'-terminal fragment of 16S rRNA complexed with 30S ribosomal proteins.

UniProtKB Entries (1)

P0AA43
RSUA_ECOLI
Escherichia coli K-12
Ribosomal small subunit pseudouridine synthase A

PDB Structure

PDB 1KSL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the 16S rRNA pseudouridine synthase RsuA bound to uracil and UMP.
Sivaraman, J., Sauve, V., Larocque, R., Stura, E.A., Schrag, J.D., Cygler, M., Matte, A.
Nat.Struct.Biol.