CATH Domain 1ks9A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1040	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
	1.10.1040.10	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family	2-dehydropantoate 2-reductase

Enzyme Information

1.1.1.169

2-dehydropantoate 2-reductase.

based on mapping to UniProt P0A9J4

(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH.

UniProtKB Entries (1)

PANE_ECOLI

Escherichia coli K-12

2-dehydropantoate 2-reductase

PDB Structure

PDB	1KS9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of Escherichia coli ketopantoate reductase at 1.7 A resolution and insight into the enzyme mechanism. Matak-Vinkovic, D., Vinkovic, M., Saldanha, S.A., Ashurst, J.L., von Delft, F., Inoue, T., Miguel, R.N., Smith, A.G., Blundell, T.L., Abell, C. Biochemistry