CATH Domain 1khkA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.720	Alkaline Phosphatase, subunit A
	3.40.720.10	Alkaline Phosphatase, subunit A

Domain Context

CATH Clusters

Superfamily	Alkaline Phosphatase, subunit A
Functional Family	Alkaline phosphatase

Enzyme Information

3.1.3.1

Alkaline phosphatase.

based on mapping to UniProt P00634

A phosphate monoester + H(2)O = an alcohol + phosphate.

-!- Active at a high pH optimum. -!- Wide specificity. -!- Also catalyzes transphosphorylations. -!- Some enzymes hydrolyze diphosphate (cf. EC 3.6.1.1).

UniProtKB Entries (1)

P00634

PPB_ECOLI

Escherichia coli K-12

Alkaline phosphatase

PDB Structure

PDB	1KHK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase. Le Du, M.H., Lamoure, C., Muller, B.H., Bulgakov, O.V., Lajeunesse, E., Menez, A., Boulain, J.C. J.Mol.Biol.