CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.630 | Aminopeptidase | |
3.40.630.30 | Gcn5-related N-acetyltransferase (GNAT) |
Domain Context
CATH Clusters
Superfamily | 3.40.630.30 |
Functional Family |
Enzyme Information
2.3.1.184 |
Acyl-homoserine-lactone synthase.
based on mapping to UniProt P54656
An acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine = [acyl-carrier- protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone.
-!- Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. -!- Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes. -!- N-(3-oxohexanoyl)-[acyl-carrier-protein] and hexanoyl-[acyl-carrier- protein] are the best substrates. -!- The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier-protein] rather than from fatty-acid degradation through acyl-CoA. -!- S-adenosyl-L-methionine cannot be replaced by methionine, S-adenosylhomocysteine, homoserine or homoserine lactone.
|
UniProtKB Entries (1)
P54656 |
ESAI_PANSE
Pantoea stewartii subsp. stewartii
Acyl-homoserine-lactone synthase
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PDB Structure
PDB | 1K4J |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structural basis and specificity of acyl-homoserine lactone signal production in bacterial quorum sensing.
Mol.Cell
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