CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1400 | Penicillin amidase (Acylase) alpha subunit, N-terminal domain |
|
1.10.1400.10 | Aminohydrolase, alpha-helical knob region |
Domain Context
CATH Clusters
| Superfamily | 1.10.1400.10 |
| Functional Family |
Enzyme Information
| 3.5.1.93 |
Glutaryl-7-aminocephalosporanic-acid acylase.
based on mapping to UniProt Q9L5D6
(7R)-7-(4-carboxybutanamido)cephalosporanate + H(2)O = (7R)-7- aminocephalosporanate + glutarate.
-!- Forms 7-aminocephalosporanic acid, a key intermediate in the synthesis of cephem antibiotics. -!- It reacts only weakly with cephalosporin C.
|
UniProtKB Entries (1)
| Q9L5D6 |
G7AC_BREDI
Brevundimonas diminuta
Glutaryl-7-aminocephalosporanic-acid acylase
|
PDB Structure
| PDB | 1JVZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of cephalosporin acylase in complex with glutaryl-7-aminocephalosporanic acid and glutarate: insight into the basis of its substrate specificity
CHEM.BIOL.
|