CATH Domain 1jqwA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1360	Gyrase A; domain 2
	3.30.1360.80	S-ribosylhomocysteinase (LuxS)

Domain Context

CATH Clusters

Superfamily	S-ribosylhomocysteinase (LuxS)
Functional Family

Enzyme Information

4.4.1.21

S-ribosylhomocysteine lyase.

based on mapping to UniProt O34667

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5- dihydroxypentan-2,3-dione.

-!- The 4,5-dihydroxypentan-2,3-dione formed spontaneously cyclizes and combines with borate to form an autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which is used by many bacteria to control gene expression in response to cell density. -!- Formerly EC 3.2.1.148 and EC 3.3.1.3.

UniProtKB Entries (1)

O34667

LUXS_BACSU

Bacillus subtilis subsp. subtilis str. 168

S-ribosylhomocysteine lyase

PDB Structure

PDB	1JQW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The 1.2 A structure of a novel quorum-sensing protein, Bacillus subtilis LuxS Ruzheinikov, S.N., Das, S.K., Sedelnikova, S.E., Hartley, A., Foster, S.J., Horsburgh, M.J., Cox, A.G., McCleod, C.W., Mekhalfia, A., Blackburn, G.M., Rice, D.W., Baker, P.J. J.Mol.Biol.