CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1170.60
Functional Family DNA polymerase eta subunit

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q04049
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q04049
POLH_YEAST
Saccharomyces cerevisiae S288C
DNA polymerase eta

PDB Structure

PDB 1JIH
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis
Trincao, J., Johnson, R.E., Escalante, C.R., Prakash, S., Prakash, L., Aggarwal, A.K.
Mol.Cell