CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.430 | Dihydrofolate Reductase, subunit A | |
3.40.430.10 | Dihydrofolate Reductase, subunit A |
Domain Context
CATH Clusters
Superfamily | Dihydrofolate Reductase, subunit A |
Functional Family | Bifunctional dihydrofolate reductase-thymidylate synthase |
Enzyme Information
2.1.1.45 |
Thymidylate synthase.
based on mapping to UniProt P13922
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
|
1.5.1.3 |
Dihydrofolate reductase.
based on mapping to UniProt P13922
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.
|
UniProtKB Entries (1)
P13922 |
DRTS_PLAFK
Plasmodium falciparum K1
Bifunctional dihydrofolate reductase-thymidylate synthase
|
PDB Structure
PDB | 1J3K |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Insights into antifolate resistance from malarial DHFR-TS structures.
NAT.STRUCT.BIOL.
|